Interaction between clock genes, melatonin and cardiovascular outcomes from ICU patients.

ABSTRACT:

Background

Circadian rhythms, driven by biological clocks, help organisms align their physiological functions with environmental changes, promoting homeostasis. The central clock in the suprachiasmatic nucleus coordinates peripheral clocks via neurohumoral feedback involving proteins like CLOCK, BMAL1, CRY 1/2, and PER 1-3. In the ICU, these circadian processes often face disruptions from constant lighting, noise, and irregular sleep-wake cycles, impairing sleep quality and worsening stress responses. These disruptions can lead to adverse clinical effects, including higher cardiovascular complication rates. This study examines how ICU stays affect circadian rhythm regulators and their association with cardiovascular outcomes.

Results

Significant differences were identified i

SUBMITTER: Jimenez-Pastor JM 

PROVIDER: S-EPMC11832861 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature