Astragalin relieves inflammatory pain and negative mood in CFA mice by down-regulating mGluR5 signaling pathway.

ABSTRACT: As a flavonoid compound, astragalin (AST) is found in a variety of medicinal plants. In clinical studies, AST has anti-inflammatory and analgesia effects on rheumatoid arthritis, bronchopneumonia diseases and so on, but its specific role and mechanism is still not clear. This study aimed to investigate the effect and molecular mechanism of AST on inflammatory pain and pain-related emotions in complete Freund's adjuvant (CFA) mice. In this study, we observed that AST significantly alleviated CFA-induced inflammatory pain and associated emotional disturbances in mice. The mechanism may be related to down-regulating mGluR5-mediated PKC_λ-ERK1/2-FOXO6 signaling pathway in CFA mice. Treatment with the mGluR5-specific inhibitor MTEP resulted in the downregulation of proteins associated

SUBMITTER: Zhang R 

PROVIDER: S-EPMC11832914 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature