Host-specific targets of Histomonas meleagridis antigens revealed by immunoprecipitation.

ABSTRACT: Histomonas meleagridis, a protozoan parasite responsible for histomonosis (syn. Blackhead disease, histomoniasis), presents an increasing challenge for poultry health, particularly with the ban of licensed prophylactic and treatment options. Recent studies have explored H. meleagridis proteome, exoproteome, and surfaceome, linking molecular data to virulence and in vitro attenuation. Nevertheless, proteins involved in interactions with hosts remain largely unknown. In this study, we conducted immunoproteome analyses to identify key antigens involved in the humoral immune response of the parasite's main hosts, turkeys and chickens. Immunogenic proteins were isolated via immunoprecipitation using sera from chickens and turkeys that were vaccinated with a single attenuated strain and challeng

SUBMITTER: de Jesus Ramires M 

PROVIDER: S-EPMC11832935 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature