Clinical characteristics of EGFR-ctDNA shedders in EGFR-mutant NSCLC patients.

ABSTRACT:

Background

Circulating tumor DNA (ctDNA) revolutionized the molecular diagnostics of lung cancer by enabling non-invasive, sensitive identification of actionable mutations. However, ctDNA analysis may be challenging due to tumor shedding variability, leading to false negative results. This study aims to understand the determinants for ctDNA shedding based on clinical characteristics of lung cancer patients, for a better interpretation of false negative results to be considered when ordering ctDNA analysis for clinical practice.

Methods

Blood samples were collected from patients with stage IV EGFR-mutated (mEGFR) NSCLC before treatment and monitored until disease progression. EGFR was assessed on tissue by standard procedures, while EGFR status on ctDNA was tested using dPCR

SUBMITTER: Ruglioni M 

PROVIDER: S-EPMC11832947 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature