Advances in macro-bioactive materials enhancing dentin bonding.

ABSTRACT: The long-term stability of dentin bonding is equally crucial for minimally invasive aesthetic restoration. Although the dentin bonding meets clinical standards at the initial stage, its long-term efficacy remains suboptimal owing to the impact of physiological factors. Herein, we present a comprehensive analysis of macro-bioactive materials, including nanomaterials and polymer materials, to improve the longevity of dentin bonding and extend the lifespan of adhesive prosthetics through various mechanisms to achieve sustained and stable dentin bonding effects over an extended period. On the one hand, the macro-bioactive materials directly inhibit the enzymatic activity of matrix metalloproteinases (MMPs) or impede the acidogenic abilities of cariogenic microorganisms, thereby enhancing the l

SUBMITTER: Fan J 

PROVIDER: S-EPMC11832989 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature