Excessive lymph node dissection increases postoperative cardiovascular disease risk in non-small cell lung cancer patients.

ABSTRACT: Heart disease is the second leading cause of death in lung cancer (LC) patients, with postoperative cardiovascular disease (CVD) commonly linked to lymph node dissection (LND). This study aimed to clarify the optimal number of lymph nodes (LNs) to be dissected by investigating the impact of LND on CVD related death in patients with surgically resected non-small cell lung cancer (NSCLC). We analyzed data from the Surveillance, Epidemiology, and End Results (SEER) database for a total of 154,566 patients with stage IA-IIIA NSCLC that underwent curative surgery from 2000 to 2020, and further validated using clinical data from a single-center cohort. For patients with negative lymph nodes, the optimal LND threshold was 3 without RT (SHR = 0.909, 95% CI: 0.841-0.982, p = 0.016) and 11 with RT (

SUBMITTER: Liang X 

PROVIDER: S-EPMC11833044 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature