Human cytomegalovirus UL82 promotes cell cycle progression of colorectal cancer by upregulating AGR2.

ABSTRACT: The correlation between persistent human cytomegalovirus (HCMV) infection and poor prognosis in colorectal cancer (CRC) patients has garnered increasing attention. UL82 is a tegument protein of HCMV, and our previous research indicated that the presence of UL82 is significantly associated with reduced overall survival in CRC patients. However, the mechanism by which UL82 affects the prognosis of CRC patients remains unclear. In this study, we investigated the role of UL82 in CRC progression through both in vitro and in vivo experiments, and revealed its downstream regulatory pathways by integrating transcriptomics, metabolomics, and proteomics. Our findings first revealed that UL82 significantly promoted CRC cell proliferation by increasing the proportion of cells in the S phase of the cel

SUBMITTER: Ren H 

PROVIDER: S-EPMC11833063 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature