Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides.

ABSTRACT: The advent of antibiotic resistance in microorganisms requires the discovery and synthesis of novel antibiotics. At the same time, human pathogens are contributing to chronic and persistent inflammation. Motivated by these two concerning issues, new antibiotic drug candidates are synthesized by incorporation of benzothiazine, pyrazole, and amide moieties in a new scaffold to create multifunctional derivatives of pyrazolo-1,2-benzothiazine. The presented compounds have been synthesized and analyzed using spectroscopic and spectrometric techniques including FTIR, HRMS, ¹H and ¹³C NMR spectroscopy. All compounds were tested against five human microbial strains including three different strains of Staphylococcus aureus (ATCC 25923, ATCC BAA-41, and ATCC BAA-44),

SUBMITTER: Saeed A 

PROVIDER: S-EPMC11833175 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature