Interpreting the Influence of Using Blood Donor Residual Samples for SARS-CoV-2 Seroprevalence Studies in Japan: Cross-Sectional Survey Study.

ABSTRACT:

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Background: Residual blood donor samples are commonly used in SARS-CoV-2 seroepidemiological studies; however their use may introduce bias due to the healthy donor effect, wherein blood donors are generally healthier than the general population. This potential bias is critical for accurately interpreting seroepidemiological data, as blood donors might not fully represent broader population-level infection rates., Objective: This study aims to assess the potential bias in SARS-CoV-2 seroprevalence estimates derived from blood donor samples in Japan by examining the association between blood donation history and COVID-19 diagnosis. By quantifying the healthy donor effect, we seek to refine the interpretation of SARS-CoV-2 seroepidemiological studies using residual blood do

SUBMITTER: Kinoshita R 

PROVIDER: S-EPMC11833190 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature