Relationship Between FODMAP Diet and Irritable Bowel Syndrome: A Mendelian Randomization Study.

ABSTRACT: There is some evidence of a link between fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet and irritable bowel syndrome (IBS). However, few studies have analyzed the relationship between specific dietary intakes and IBS using Mendelian randomization (MR). Exposure and outcome datasets were sourced from the IEU Open GWAS project. Genetic variants significantly associated with 28 dietary intakes at a genome-wide level were selected as instrumental variables. Summary statistics for the target outcome of IBS were obtained with a sample of 187,028 European individuals (4605 cases, 182,423 controls). Univariable and multivariable MR analyses were conducted to estimate the overall and independent MR associations after adjustment for genetic liability to intest

SUBMITTER: Wang L 

PROVIDER: S-EPMC11833296 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature