Relationships Between Glymphatic System Activity and Tau Burden, Dopaminergic Impairment, Abnormal Glucose Metabolism in Progressive Supranuclear Palsy.

ABSTRACT:

Background

Progressive supranuclear palsy (PSP) is a primary tauopathy characterized by dopaminergic impairment and abnormal glucose metabolism. The glymphatic system can promote the elimination of tau protein. The association between glymphatic function and pathological hallmark in neuroimaging remains unknown.

Methods

Diffusion tensor imaging (DTI) and positron emission tomography (PET) scanning with ¹⁸F-Florzolotau, ¹⁸F-FPCIT, and ¹⁸F-FDG were performed in PSP patients. DTI analysis along the perivascular space (ALPS) index was computed to assess glymphatic function, while the semi-quantitative value was employed to measure tau burden and dopaminergic impairment. The PSP-related pattern (PSPRP) served as an indicator of abnormal metabolic

SUBMITTER: Jiao F 

PROVIDER: S-EPMC11833299 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature