Single nucleotide polymorphism and promoter methylation analysis of protein tyrosine phosphatase 1B in patients with myeloproliferative neoplasms.

ABSTRACT:

Background

The recurrent somatic mutations in genes such as Janus kinase 2 (JAK2) lead to cytokine-independent activation of the JAK-signal transducer and activator of transcription (STAT) pathway, a crucial factor in the development of classic myeloproliferative neoplasms (cMPNs). Protein tyrosine phosphatase 1B (PTP1B) is a significant regulator in this pathway, while the single nucleotide polymorphism (SNP) and promoter methylation profiles of the PTP1B gene in cMPN patients have largely remained unexplored. Therefore, to further explore the SNP and promoter methylation profiles of the PTP1B gene in cMPNs, we conducted a comprehensive SNP analysis of the PTP1B gene as well as the methylation status detection of the PTP1B promoter between cMPN patients

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11833361 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature