FTO-mediated m⁶A demethylation of SERPINE1 mRNA promotes tumor progression in hypopharyngeal squamous cell carcinoma.

ABSTRACT:

Background

The fat mass and obesity-associated protein (FTO) is implicated in various diseases and acts as a demethylase for the most abundant modification of mRNA, namely N6-methyladenosine (m⁶A) modification. It is known that FTO may play an oncogenic role or a tumor-suppressor role in different malignancies. The aim of this study was to investigate the functional roles of FTO in regulating biological processes related to hypopharyngeal squamous cell carcinoma (HSCC).

Methods

Using immunohistochemistry, quantitative real-time polymerase chain reaction (RT-qPCR), and Western blot analysis, we compared the expression levels of FTO in HSCC tissues to adjacent non-cancerous tissues. Furthermore, we evaluated the prognosis of patients with hypopharyngeal cancer in re

SUBMITTER: Sa N 

PROVIDER: S-EPMC11833370 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature