Analysis and exploration of regulatory mechanisms and potential prognostic biomarkers in squamous cell carcinoma of the lung by expression profiling.

ABSTRACT:

Background

Lung cancer is the most common malignant tumor in China. In 2016, more than 800,000 new cases of lung cancer were diagnosed in China. Squamous cell carcinoma of the lung, a type of non-small cell lung cancer (NSCLC), accounts for 25-30% of all lung cancer cases, and has an overall 5-year survival rate of about 32.53%, lower than adenocarcinoma for which there have been far more therapeutic advances in the last few decades. The purpose of this study was to explore the mechanisms of the disease and to identify potential prognostic biomarkers.

Methods

This study analyzed lung squamous cell carcinoma of the lung tissues and paraneoplastic tissues to identify differentially expressed genes (DEGs). We conducted a Gene Set Enrichment Analysis and prognostic analysis by c

SUBMITTER: Wan X 

PROVIDER: S-EPMC11833388 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature