Association between serum urate levels, gout and breast cancer: observational and Mendelian randomization analyses.

ABSTRACT:

Background

It is hypothesized that uric acid acts as an antioxidant and may prevent cancer. However, observational studies regarding the relationship between serum urate levels, gout, and breast cancer have provided discrepant evidence. Therefore, the objective of our study was to investigate the potential causal relationship between them.

Methods

This study included 12,451 participants from the National Health and Nutrition Examination Survey (NHANES) 2009-2018. Associations between urate levels, gout, and breast cancer were examined using multivariate logistic regression analysis. In addition, to assess the causal link among them, Mendelian randomization (MR) analysis was conducted, primarily using the inverse variance weighted (IVW) approach, supplemented by MR Egger and

SUBMITTER: Wang S 

PROVIDER: S-EPMC11833399 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature