Level and clinical significance of serum CXC chemokine ligand 13 in patients with hepatocellular carcinoma.

ABSTRACT:

Background

CXC chemokine ligand 13 (CXCL13) serves as the ligand for chemokine receptor 5 (CXCR5), The CXCL13/CXCR5 signaling axis plays a crucial role in the pathogenesis and progression of various malignancies. This study aimed to assess the expression and role of serum CXCL13 in patients with hepatocellular carcinoma (HCC) and explore its clinical significance in the diagnosis, treatment, and prognosis evaluation of HCC.

Methods

Serum samples and clinical data were collected from 74 HCC patients, 51 cirrhosis patients, and 53 healthy controls. The expression level of serum CXCL13 was measured using enzyme-linked immunosorbent assay (ELISA). Statistical software was employed to analyze the relationship between CXCL13 levels and clinicopathological features as well as labor

SUBMITTER: Wu YT 

PROVIDER: S-EPMC11833404 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature