Testosterone and colorectal cancer: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Although Mendelian randomization (MR) studies have been conducted on the causal relationship of testosterone on colorectal cancer (CRC), the result remains controversial. We aimed to explore the genetically determined relationships between total testosterone (TT) and bioavailable testosterone (BT) with CRC using a larger sample size and more stringent methods to exclude confounding factors.

Methods

Based on genome wide association studies (GWAS) data of TT, BT and CRC, we utilized bidirectional two-sample MR methods to analyze their interrelationships. Causal relationship analysis was conducted using inverse variance weighting (IVW), MR-Egger, weighted median, simple mode and weighted mode. Sensitivity analyses were performed to examine the stability of the causal

SUBMITTER: Li J 

PROVIDER: S-EPMC11833406 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature