Cuproptosis-related genes signature could predict prognosis and the response of immunotherapy in cervical cancer.

ABSTRACT:

Background

A lot of studies have shown a close relationship between cuproptosis and cancer. The main purpose of this study is to analyze the impact of cuproptosis on cervical cancer (CC).

Methods

Using The Cancer Genome Atlas (TCGA) public database, we analyzed the genetic correlation, expression, and prognostic value of 25 cuproptosis-related genes (CRGs) in CC. A least absolute shrinkage and selection operator (LASSO) risk regression model was constructed to compare the changes in associated pathways, prognosis, immune infiltration, and antibody programmed cell death-ligand 1 (anti-PD-L1) treatment response of the high- and low-risk groups. In addition, we collected CC tissue samples before and after radiotherapy for ribonucleic acid (RNA) sequencing, and analyzed the rela

SUBMITTER: Liu X 

PROVIDER: S-EPMC11833422 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature