Hydrogen Sulfide Alleviates Schizophrenia-Like Behavior Through Regulating Apoptosis by S-Sulfhydrylation Modification.

ABSTRACT:

Background

We initiated an exploration of the relationship between hydrogen sulfide (H₂S) and Schizophrenia (SZ) as well as its mechanism at the three levels of population study, cellular investigation, and animal model.

Materials and methods

Clinical data and peripheral blood samples from 78 patients with SZ and 83 healthy controls (HC) were collected for the detection of H₂S levels (ChiCTR (Chinese Clinical Trial Registry) 900026776). MK801 (Dizocilpine) was used to establish SZ models in cells and rats, with sodium hydrosulfide (NaHS) serving as an exogenous H₂S donor. H₂S levels in plasma and hippocampal tissue of rats were measured using Enzyme Linked Immunosorbent Assay (ELISA). Terminal dUTP Nick End Labeling (TUNEL) stainin

SUBMITTER: Du X 

PROVIDER: S-EPMC11833453 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature