Clinical implementation of preemptive pharmacogenomics testing for personalized medicine at an academic medical center.

ABSTRACT:

Objective

This article describes the implementation of preemptive clinical pharmacogenomics (PGx) testing linked to an automated clinical decision support (CDS) system delivering actionable PGx information to clinicians at the point of care at UCSF Health, a large Academic Medical Center.

Methods

A multidisciplinary team developed the strategic vision for the PGx program. Drug-gene interactions of interest were compiled, and actionable alleles identified. A genotyping platform was selected and validated in-house. Following HIPAA protocols, genotype results were electronically transferred and stored in electronic health records (EHRs). CDS was developed and integrated with electronic prescribing.

Results

We developed a customized PGx program for 56 medications and 15 g

SUBMITTER: Tamraz B 

PROVIDER: S-EPMC11833476 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature