Developmental programming: preconceptional and gestational exposure of sheep to biosolids on offspring ovarian dynamics†.

ABSTRACT: Developmental exposure to environmental chemicals perturbs establishment and maintenance of the ovarian reserve across the reproductive lifetime, leading to premature follicle depletion and ovarian aging. Considering humans are exposed to a complex mixture of environmental chemicals, real-life models assessing their cumulative impact on the ovarian reserve are needed. Biosolids are a source of a real-life mixture of environmental chemicals. While earlier studies demonstrated that grazing pregnant sheep on biosolids-treated pastures did not influence establishment of the ovarian reserve in fetal life, its impact on subsequent depletion of ovarian reserve during reproductive life of offspring is unknown. We hypothesized that developmental exposure to biosolids accelerates depletion of ovaria

SUBMITTER: Halloran KM 

PROVIDER: S-EPMC11833488 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature