Effect of prostate volume on the predictive value of prostate-specific antigen density for prostate cancer.

ABSTRACT:

Background

In clinical practice, we observed that some patients with larger prostate volume (PV) and prostate-specific antigen (PSA) values below 20 ng/mL still yielded negative biopsy results. We aim to establish a more precise volume range for guiding biopsies in patients with enlarged prostate glands.

Methods

We conducted a retrospective analysis of 424 cases involving patients who underwent prostate biopsy. The patients were categorized into three groups based on their body mass index: small (PV <45 cm³), medium (45 cm³≤ PV <70 cm³), and large (PV ≥70 cm³). Logistic regression, receiver operating characteristic (ROC) curves, restricted cubic spline (RCS) curves, and decision trees were employed for comparison purposes.

Resul

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11833531 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature