Metastatic sites, prognosis, and a new nomogram for predicting overall survival among small cell lung cancer patients with liver metastasis: a retrospective study based on SEER.

ABSTRACT:

Background

Small cell lung cancer (SCLC) is acknowledged as the most aggressive histological subtype among the various types of lung cancer. Among patients with advanced-stage SCLC, liver metastasis (LM) is frequently observed and is associated with the most unfavorable prognosis. The purpose of the present study is to investigate the synchronous metastatic sites in SCLC patients with LM, and to construct a nomogram for predicting the survival of these patients.

Methods

The data of SCLC patients with LM in the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Univariate and multivariate Cox analyses were conducted to identify independent prognostic factors. A prognostic nomogram was developed and validated through calibration curves,

SUBMITTER: Li R 

PROVIDER: S-EPMC11833554 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature