Association of statin use with 28-day mortality in the Medical Information Mart for Intensive Care IV database: a retrospective cohort study.

ABSTRACT:

Background

Statins, acknowledged for their ability to reduce cardiovascular risk, demonstrate a variety of pleiotropic effects, including anti-inflammatory, antithrombotic, endothelial stabilizing activity and prevention of acute kidney injury (AKI) post cardiac surgery. Patients in the intensive care unit (ICU) face heightened risks of cardiovascular disease, infections, and thrombotic complications, but the effect of statin therapy on ICU mortality remains controversial. The Medical Information Mart for Intensive Care IV (MIMIC-IV) database is a publicly available intensive care medicine information database that includes data on critically ill patients admitted to the ICU at Beth Israel Deaconess Medical Center from 2008 to 2019, with a large sample size. In this retrospective c

SUBMITTER: Kang C 

PROVIDER: S-EPMC11833575 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature