The diagnostic value of vascular architecture in solid solitary pulmonary nodules quantified by dynamic contrast enhanced MRI.

ABSTRACT:

Background

Alterations in the vascular microenvironment of cancer have gradually gained widespread attention in oncology research, and early qualitative diagnosis using noninvasive examination techniques is crucial in clinical practice. This study aimed to explore the value of quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the assessment of vascular architecture of solid solitary pulmonary nodules (SSPNs).

Methods

DCE-MRI scan images of a total of 79 patients with SSPNs from November 2021 to December 2023 were prospectively analyzed. Quantitative permeability parameters K^trans, K_ep, and V_e values of the lesions were measured, labeled immunohistochemically with CD31 microvessel density (CD31-MVD),

SUBMITTER: Fu L 

PROVIDER: S-EPMC11833577 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature