Effect of honey, as a natural deep eutectic solvent, on the phytochemical stability and anti-inflammatory activity of <i>Eurycoma longifolia</i> Jack.

ABSTRACT: The use of Eurycoma longifolia Jack (EL) in combination with honey is widely recognized in conventional medicine because of its aphrodisiac and pyretic properties. However, the effects of honey, a natural deep eutectic solvent (NADES), on the phytochemical stability and anti-inflammatory activity of EL remain unknown. This study aimed to investigate the effect of honey on phytochemical and anti-inflammatory effects of EL. The stabilities of bioactive compounds, including eurycomanone (EU), 9-hydroxycanthine-6-one (9HCO), and 9-methoxycanthine-6-one (9MCO), were evaluated after treating EL with honey. The anti-inflammatory activity was assessed by measuring the inhibition of NO production in lipopolysaccharide-induced RAW264.7 macrophages. The EL formulations treated with honey exhib

SUBMITTER: Sitthisak C 

PROVIDER: S-EPMC11833601 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature