Unveiling ferroptosis genes and inhibitors in diabetic retinopathy through single-cell analysis and docking simulations.

ABSTRACT: Diabetic retinopathy (DR) is a common microvascular complication of diabetes and a leading cause of vision loss worldwide. Although several mechanisms have been implicated in the pathogenesis of DR, emerging evidence suggests a link between ferroptosis and DR. Unfortunately, the exact mechanism underlying this connection is not clear. Therefore, investigating the role of ferroptosis in diabetic retinopathy holds promise for advancing our understanding of this complex disease and developing innovative treatments. We have identified differentially expressed genes (DEGs) and differentially expressed marker genes (DEMGs) from open-source single-cell RNA sequencing datasets by using in depth in silico approach. Subsequently, ferroptosis-associated DEGs (FA-DEGs), ferroptosis-associated DEMGs (F

SUBMITTER: Ahamad Khan MM 

PROVIDER: S-EPMC11833632 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature