Temporal Dynamics and Biological Variability of Alzheimer Biomarkers.

ABSTRACT:

Importance

Understanding the characteristics of discordance between plasma biomarkers and positron emission tomography (PET) results in Alzheimer disease (AD) is crucial for accurate interpretation of the findings.

Objective

To compare (1) medical comorbidities affecting plasma biomarker concentrations, (2) imaging and clinical features, and (3) cognitive changes between plasma biomarker and PET discordant and concordant cases.

Design, setting, and participants

This multicenter cohort study, conducted between 2016 and 2023, included individuals with unimpaired cognition, mild cognitive impairment, or Alzheimer-type dementia, who had both amyloid β (Aβ) PET imaging and plasma biomarkers. A subset of participants also underwent tau PET imaging.

Exposures

Particip

SUBMITTER: Yun J 

PROVIDER: S-EPMC11833660 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature