Global chromatin reorganization and regulation of genes with specific evolutionary ages during differentiation and cancer.

ABSTRACT: Cancer cells are highly plastic, favoring adaptation to changing conditions. Genes related to basic cellular processes evolved in ancient species, while more specialized genes appeared later with multicellularity (metazoan genes) or even after mammals evolved. Transcriptomic analyses have shown that ancient genes are up-regulated in cancer, while metazoan-origin genes are inactivated. Despite the importance of these observations, the underlying mechanisms remain unexplored. Here, we study local and global epigenomic mechanisms that may regulate genes from specific evolutionary periods. Using evolutionary gene age data, we characterize the epigenomic landscape, gene expression regulation, and chromatin organization in several cell types: human embryonic stem cells, normal primary B-cells, p

SUBMITTER: Raynal F 

PROVIDER: S-EPMC11833689 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature