Synaptic Vesicle 2A (SV2A) Positron Emission Tomography (PET) Imaging as a Marker of Therapeutic Response in a Mouse Model of Depression.

ABSTRACT: In this preclinical pilot study, we used [¹¹C]UCB-J PET imaging to monitor the synaptic modulation in depression and after fluoxetine. PET imaging was performed in a validated mouse model of depression/anxiety (CORT model), and the effect of 5-week treatment with fluoxetine was tested. Depression/anxiety phenotype and antidepressant action of fluoxetine were confirmed using the novelty-suppressed feeding test, previously validated in the CORT model. PET data showed significant decreases of volume of distribution (V _T) of [¹¹C]UCB-J in most brain regions of CORT mice compared with controls. After 5 weeks of fluoxetine, a trend toward restoration of V _T values to control levels was observed, although it reached significance only in th

SUBMITTER: Corvo C 

PROVIDER: S-EPMC11833719 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature