Serum metabolomics analysis reveals a novel association between maternal metabolism and fetal survival in sows fed diets containing differing methionine levels and sources.

ABSTRACT: Methionine (Met) metabolism is vital for one carbon metabolism, redox status and fetal development. Hence, this study investigated the effects of different levels and sources of Met on maternal metabolism, anti-oxidative capacity and fetal survival in pregnant sows. Forty primiparous sows were assigned to the following four groups: control group (basal diet, CON), 1.5S-OHMet group (supplemented methionine hydroxy analogue [OHMet] at 1.5 g/kg diet), 3.0S-OHMet group (supplemented OHMet at 3.0 g/kg diet), and 3.0S-Met group (supplemented L-Met at 3.0 g/kg diet) (n = 10). The trial lasted from day 60 of gestation to the farrowing day. Maternal 1.5S-OHMet consumption had the lowest stillborn ratio and the highest serum glucose levels during farrowing. Further analysis revealed that diet

SUBMITTER: Zhou R 

PROVIDER: S-EPMC11833788 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature