Deep sequencing of serially passaged Sudan virus in guinea pigs uncovers adaptive mutations.

ABSTRACT: Orthoebolaviruses are non-segmented, negative sense RNA viruses that make up the genus Orthoebolavirus in the family Filoviridae. Sudan virus (SUDV) is a highly pathogenic orthoebolavirus that causes severe disease in humans. In the last 45 years, SUDV has been responsible for several outbreaks in eastern Africa, particularly in Sudan and Uganda, with an average case fatality rate of approximately 50 %. Despite having caused numerous outbreaks, including a recent outbreak in 2022, no licensed therapeutics or prophylactics currently exist for Sudan virus disease. Small animal models like mice, hamsters, and guinea pigs have paved the way for the initial evaluation of filovirus countermeasures; however, since filoviruses are apathogenic in immunocompetent rodents, they must fir

SUBMITTER: Emeterio K 

PROVIDER: S-EPMC11834042 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature