ANLN promotes head and neck squamous cell carcinoma progression by upregulating PD-L1 via the ERK-MAPK pathway.

ABSTRACT: Anillin (ANLN) is a highly conserved protein involved in cytokinesis and cytoskeletal remodeling. This study investigates the role of ANLN in head and neck squamous cell carcinoma (HNSCC) progression and its impact on the tumor immune microenvironment, with a focus on the combination of ANLN silencing and anti-programmed cell death protein 1 (PD-1) therapy. Through in vitro and in vivo experiments, along with clinical specimen analysis, we discovered that silencing ANLN not only inhibits the malignant progression of HNSCC but also reduces the activation of the extracellular signal-regulated kinase-mitogen-activated protein kinase (ERK-MAPK) signaling pathway and decreases programmed death ligand-1 (PD-L1) expression. Integrating ANLN silencing with anti-PD-1 monoclonal antibo

SUBMITTER: Wang L 

PROVIDER: S-EPMC11834070 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature