Pioneering ionic liquids in neuro-soothing: Enhanced transdermal delivery of collagen peptides and their synergistic anti-aging functions.

ABSTRACT: Facial wrinkles include static and dynamic lines formed through different mechanisms and require diverse treatment approaches. Peptides perform well in anti-aging and wrinkle removal but exhibit poor transdermal efficiency. In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA) and lactic acid (LA), is applied in the transdermal delivery of hexapeptide-9, which promotes collagen production. This treatment aims to remove dynamic and static lines simultaneously, and the human endogenous feature of GABA, LA, and hexapeptide-9 guarantees high biosafety of the system. The in-vitro transdermal, cellular, animal, and clinical experiments indicate that GALA is a safe and effective enhancer. GALA enhances the local penetration of hexapeptide-9 by altering

SUBMITTER: Wang M 

PROVIDER: S-EPMC11834113 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature