Multifunctional liposome boosts glioma ferroptosis and immunotherapy through reinforcement of chemo-dynamic therapy strategy.

ABSTRACT: Glioma remains significant challenging to completely cure by the conventional surgical resection because of its high infiltrative growth properties. Recently, emerging immunotherapy has achieved remarkable success in treating various cancer, but glioma do not benefit from cancer immunotherapy owing to its specific immunosuppressive tumor microenvironment (iTME). Herein, we show the significant improvement of the immunotherapy efficacy for glioma through multifunctional liposome (Lpo@Cu₂Se-GOx). After tumor cells endocytosis, the released glucose oxidase (GOx) could oxidize glucose into gluconic acid to achieve starvation therapy and generate H₂O₂ as byproduct. Meanwhile, these properties might further cause anti-oxidant systems dysfunction and reinforce Cu<

SUBMITTER: Chen H 

PROVIDER: S-EPMC11834134 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature