Individual mHLA-DR trajectories in the ICU as predictors of early infections following liver transplantation: a prospective observational study.

ABSTRACT:

Background

Infections are a leading cause of early mortality after liver transplantation (LT). Prior to transplantation, cirrhosis-associated immune dysfunction significantly increases the risk of infection. This study investigated the potential of immune monitoring, with a focus on monocytic HLA-DR (mHLA-DR) expression, as a predictor of post-LT complications.

Methods

We conducted a prospective study on 130 patients awaiting LT at Lyon University Hospital to assess mHLA-DR expression, lymphocyte subsets, and T-cell function before and after LT. Multivariate analysis and K-means longitudinal clustering were performed to explore the relationships between immune trajectories and clinical outcomes.

Results

Among the 99 patients who underwent LT, 35.4% experienced infecti

SUBMITTER: Delignette MC 

PROVIDER: S-EPMC11834174 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature