Thyroid hormones and frailty in older adults: systematic review and dose-response meta-analysis.

ABSTRACT:

Objective

To investigate (1) whether the association of thyroid hormone with frailty risk is linear or nonlinear and (2) which range of thyroid hormones or thyroid stimulating hormone (TSH) is more associated with a higher risk of frailty in older adults.

Design

Systematic review and dose-response meta-analysis.

Methods

Medical electronic databases were searched for cross-sectional or longitudinal studies, published from database inception to February 2022. We focused on the relationship between TSH and frailty. Data on TSH reference range, TSH exposure categories, sample size of each exposure category, and adjusted odds ratios (ORs) for frailty with 95% confidence interval (CI) were extracted. In the dose-response meta-analysis, we set the OR for frailty as 1 at 0.3

SUBMITTER: Chia WC 

PROVIDER: S-EPMC11834251 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature