Elevated levels of PAI-1 precede the occurrence of type 2 diabetes mellitus.

ABSTRACT:

Aims

Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of the fibrinolytic system and is mainly secreted from adipose tissue. It is associated with cardiovascular disease and has also been considered a possible early risk marker for type 2 diabetes. Here, we present the results of a large prospective study investigating PAI-1 levels in relation to incident type 2 diabetes mellitus.

Methods

We conducted a prospective incident case-referent study within the Västerbotten Intervention Programme (VIP). Data on cardiovascular risk factors, fasting plasma glucose (FPG) and 2-hour plasma glucose (2-hPG) were collected at baseline health examination 1990-2005. Blood samples were collected and stored for future analyses. Participants were followed and 484 cases developed

SUBMITTER: Hernestal-Boman J 

PROVIDER: S-EPMC11834294 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature