Stereotactic body radiotherapy with carbon ions as local ablative treatment in patients with primary liver cancer.

ABSTRACT:

Background and aims

Liver cancer is the third leading cause of cancer related death due to treatment resistance and late onset of symptoms (Rumgay in J Hepatol 77: 1598-1606, 2022). The role of external beam radiotherapy (EBRT) in treatment of unresectable liver cancer needs to be defined. The use of particle therapy such as carbon ion radiation therapy (CIRT) with high linear energy transfer (LET) could increase efficacy of EBRT while limiting the toxic effects of radiation on non-cancerous liver tissue. Promising effects of CIRT have been described in several studies during the past decades, mostly in Japan. To date, no standardized treatment protocol has been established and European data on CIRT for liver cancer is lacking. This retrospective analysis aims to investigate effica

SUBMITTER: Hoffmeister-Wittmann P 

PROVIDER: S-EPMC11834390 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature