Tracking clonal and plasmid transmission in colistin- and carbapenem-resistant <i>Klebsiella pneumoniae</i>.

ABSTRACT: The surveillance of mobile genetic elements facilitating the spread of antimicrobial resistance genes has been challenging. Here, we tracked both clonal and plasmid transmission in colistin- and carbapenem-resistant Klebsiella pneumoniae using short- and long-read sequencing technologies. We observed three clonal transmissions, all containing Incompatibility group (Inc) L plasmids and New Delhi metallo-beta-lactamase bla_NDM-1, although not co-located on the same plasmid. One IncL-bla_NDM-1 plasmid had been transferred between sequence type (ST) 392 and ST15, and the promiscuous IncL-bla_OXA-48 plasmid was likely shared between a singleton and a clonal transmission of ST392. Plasmids within clonal outbreaks and between clusters and

SUBMITTER: Akintayo I 

PROVIDER: S-EPMC11834398 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature