Airway <i>Corynebacterium</i> interfere with <i>Streptococcus pneumoniae</i> and <i>Staphylococcus aureus</i> infection and express secreted factors selectively targeting each pathogen.

ABSTRACT: The composition of the respiratory tract microbiome is a notable predictor of infection-related morbidities and mortalities among both adults and children. Species of Corynebacterium, which are largely present as commensals in the upper airway and other body sites, are associated with lower colonization rates of opportunistic bacterial pathogens such as Streptococcus pneumoniae and Staphylococcus aureus. In this study, Corynebacterium-mediated protective effects against S. pneumoniae and S. aureus were directly compared using in vivo and in vitro models. Pre-exposure to Corynebacterium pseudodiphtheriticum reduced the ability of S. aureus and S. pneumoniae to infect the lungs of mice, indicating a broadly protecti

SUBMITTER: Tamkin E 

PROVIDER: S-EPMC11834435 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature