Boronic acid-functionalized Fe₃O₄ nanoparticles for activity-preserved enrichment of low-abundance bacteria from real samples.

ABSTRACT: Pathogenic bacterial infections represent a significant and ongoing threat to public health. The development of a sensitive, convenient, and accurate method for diagnosing pathogenic bacteria is a formidable challenge due to their low abundance in complex biological samples, especially in the early stages of diseases. In this study, a kind of phenylboronic acid-functionalized Fe₃O₄ nanoparticles (NPs), known as Fe₃O₄@poly(PEGDA-co-MAAPBA) NPs, was developed for effectively enriching low levels of pathogenic bacteria from complex samples and then diagnosing them through microbiological cultures. In this design, the resultant Fe₃O₄@poly(PEGDA-co-MAAPBA) NPs could recognize pathogenic bacteria because of the rever

SUBMITTER: Chen J 

PROVIDER: S-EPMC11834453 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature