Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses.

ABSTRACT: Tumor-resident immune cells play a crucial role in eliciting anti-tumor immunity and immunomodulatory drug responses, yet these functions have been difficult to study without tractable models of the tumor immune microenvironment (TIME). Patient-derived ex vivo models contain authentic resident immune cells and therefore, could provide new mechanistic insights into how the TIME responds to tumor or immune cell-directed therapies. Here, we assessed the reproducibility and robustness of immunomodulatory drug responses across two different ex vivo models of breast cancer TIME and one of renal cell carcinoma. These independently developed TIME models were treated with a panel of clinically relevant immunomodulators, revealing remarkably similar changes in gene expression and cytok

SUBMITTER: Turpin R 

PROVIDER: S-EPMC11834457 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature