HOTAIR expression as a biomarker in glioblastoma multiforme: a comprehensive meta-analysis of current evidence.

ABSTRACT:

Purpose

Glioblastoma multiforme (GBM) is an aggressive brain tumor. This meta-analysis investigates the association between HOTAIR expression levels and GBM.

Methods

We searched the literature for studies on HOTAIR expression in GBM patients. A meta-analysis of nine studies assessed standardized mean difference (SMD) and 95% confidence intervals (CIs) using a random-effects model. Subgroup analyses were performed based on sample source, country, and study design. Additionally, we conducted meta-regression and publication bias analyses.

Results

The meta-analysis found a significant positive association between elevated HOTAIR expression and GBM (SMD = 8.3, 95% CI 5.8-10.8, p = 0.00). Considerable heterogeneity was observed (Q-value: 1174.2, df = 9, I²

SUBMITTER: Bahranian A 

PROVIDER: S-EPMC11834459 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature