Gut microbiota dysbiosis and associated immune response in systemic lupus erythematosus: impact of disease and treatment.

ABSTRACT:

Background

Gut microbial dysbiosis and leaky gut play a role in systemic lupus erythematosus (SLE). Geographical location and dietary habits affect the microbiome composition in diverse populations. This study explored the gut microbiome dysbiosis, leaky gut, and systemic immune response to gut bacterial consortium in patients with SLE exhibiting mild/moderate and severe disease activity.

Methods

Fecal and blood samples were collected from patients with SLE and healthy volunteers. Genomic DNA was extracted from the stool samples and subjected to 16S rRNA amplicon sequencing and microbiome profiling. Additionally, enzyme-linked immunosorbent assays were employed to determine the serum lipopolysaccharide level, as an assessment of gut permeability, and the systemic immune resp

SUBMITTER: Ali AY 

PROVIDER: S-EPMC11834511 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature