Age at type 1 diabetes onset does not influence attained brain volume.

ABSTRACT:

Introduction

Type 1 diabetes is suspected to hamper brain growth, implying that people with earlier diabetes onset would, on average, achieve lower maximal brain volume. We set out to test this hypothesis.

Methods

Examining brain MRI scans of middle-aged people with type 1 diabetes, we related age at diabetes onset to intracranial volume in 180 participants, as well as to cerebral gray and white matter volumes in a subset of 113 (63%) participants, using fractional polynomial regression models. Of the participants, 118 (67%) had been diagnosed with diabetes before 18 years of age.

Results

Of our participants, 54% were women, the median age 40.0 (IQR 33.2-45.0) years and the range of age at diabetes onset was 1.2-39.0 years. We found no association between age at diabe

SUBMITTER: Claesson TB 

PROVIDER: S-EPMC11834590 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature