Toxic effects of prolonged propofol exposure on cardiac development in zebrafish larvae.

ABSTRACT:

Background

Propofol, commonly used as an intravenous anesthetic during pregnancy, can easily penetrate the placental barrier, potentially affecting fetal heart development. This study aims to investigate propofol's impact on developing zebrafish heart structure and function, and identify potential drug targets.

Methods

Zebrafish embryos were exposed to different concentrations of propofol (0.5, 1, and 5 mg/L) to observe changes in zebrafish larval heart structure and function (heart rate). In vitro cell experiments were conducted to assess the effects of propofol at different concentrations on cardiomyocyte viability and migration. Transcriptomic sequencing was utilized to identify and validate potential drug targets associated with propofol-induced cardiac toxicity.

Resu

SUBMITTER: Qian S 

PROVIDER: S-EPMC11834635 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature