Efficacy and safety of tetracycline vs. amoxicillin in furazolidone-based rescue therapy for <i>Helicobacter pylori</i>: a real-world analysis.

ABSTRACT:

Background and aim

Despite the increasing rates of antibiotic resistance, furazolidone-based regimens have demonstrated promise in Helicobacter pylori eradication. Therefore, this study aims to evaluate the comparative efficacy and safety of tetracycline versus amoxicillin in furazolidone-based quadruple therapy [bismuth quadruple therapy with furazolidone and tetracycline (BQFT) vs. bismuth quadruple therapy with furazolidone and amoxicillin (BQFA)] in rescue treatments.

Methods

Patients who received BQFT or BQFA as rescue treatment were enrolled in this study. H. pylori status was determined using the ¹³C/¹⁴C urea breath test or histological examination. Eradication rates, adherence and side effects were carefully recorded.

Results

SUBMITTER: Xie J 

PROVIDER: S-EPMC11834778 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature