Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples.

ABSTRACT: Association genome scanning is of increasing interest for identifying the chromosomal regions that contain gene variants that contribute to vulnerability to complex disorders, including addictions. To improve the power and feasibility of this approach, we have validated "10k" microarray-based allelic frequency assessments in pooled DNA samples and have used this approach to seek allelic frequency differences between heavy poly-substance abusers and well characterized control individuals. Thirty-eight loci contain SNPs that display robust allele frequency differences between abusers and controls in both European- and African-American samples. These loci identify an alcohol/acetaldehyde dehydrogenase gene cluster and genes implicated in cellular signaling, gene regulation, development, "cell

SUBMITTER: Liu QR 

PROVIDER: S-EPMC1183486 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature