Autoantibodies in myasthenia gravis: cluster analysis and clinical correlations.

ABSTRACT:

Objective

This study aimed to explore autoantibody clusters and their correlations with clinical features in 644 myasthenia gravis (MG) patients.

Methods

Medical records of 664 MG patients were reviewed. Five autoantibodies (AChR, MuSK, titin, RyR, and LRP4) were selected for cluster analysis. The various clinical manifestations were compared between clusters. Separate association analyses between individual autoantibodies and clinical manifestations as well as among different MGFA subtypes were also performed without prior clustering.

Results

Two separate autoantibody clusters were identified, with significantly different clinical manifestations. Cluster 1 (485 patients) was characterized by higher proportions of RyR-, titin-, and AChR-, while cluster 2 (179 patients

SUBMITTER: Sun X 

PROVIDER: S-EPMC11834866 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature